The exact same process used to make beer can be altered to ferment sugars and other renewable resources such as agricultural waste into a plethora of valuable chemicals, provided that we can reliably design and manipulate novel metabolic pathways that convert the starting material (feedstock) into the ultimate desired product. The primary challenge lies in the fact that the chemicals and material building blocks of most interest to the chemical industry are not known to be made by natural organisms or any existing metabolic pathways. To truly be able to reliably and systematically create designer cell factories for the production of current and new chemicals of interest, one need to satisfy two experimental constraints. One, design novel metabolic pathways employing the necessary enzymatic building blocks to process feedstock to final product the same way that wheat ultimately turns into beer. Two, integrate these novel pathways in a cellular chassis and optimize them to reach the desired level of yield, concentration and purity.